ibs-smart® for Irritable Bowel Syndrome (IBS-D)
Test Introduction
The ibs-smart test serves as a diagnostic aid for IBS by providing relevant immunological information about antibodies to cytothelial distending toxin B (CdtB) and vinculin. Post-infectious IBS-D (diarrhea-predominant) is likely caused by food-borne gastric infections known as “food poisoning.” The most common bacteria causing food poisoning are Shigella, Campylobacter, C. difficile, Salmonella, and E.coli.
Bacteria release a toxin called CdtB into the body which the immune system recognizes as foreign. Immune cells produce anti-CdtB antibodies which also recognize a naturally occurring protein in the body called vinculin. While the anti-CdtB antibodies are fighting the bacterial toxin, the anti-vinculin antibodies produce an auto-immune response leading to gut nerve damage and post-infection irritable bowel syndrome.
The ibs-smart test was optimized by ResearchDx scientists and is an enzyme-linked immunosorbent (ELISA) assay to assess circulating antibody levels anti-CdtB and anti-vinculin. The test does not provide an exclusive diagnosis of IBS and results should be interpreted in the context of the patient’s clinical and laboratory findings.
For more information about ordering this blood test for IBS, visit: ibs.smart.com
Test Description
Enzyme-linked immunosorbent (ELISA) assay is used to assess circulating antibody levels of CdtB and vinculin in patients exhibiting symptoms of IBS. The assay does not provide an exclusive diagnosis of IBS. Results should be interpreted in the context of the patient’s clinical and laboratory findings.
Test Ordering
The test may be ordered through the center for rare inherited disorders through Gemelli Biotech and the IBSSmart Website. This test was developed, and its analytical performance characteristics have been determined by PacificDx. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Sample Collection and Shipping Instructions
Collect a total of 20 mL of whole blood into the 2 K2-EDTA tubes, ship 15-25C within 24 hrs of collection.
The Tasso collection kit must be collected in accordance with the kit instruction, and shipped in the provided mailer with 24 hours of collection.
