⦁ At PacificDx we run a proprietary q-PCR based assay designed to detect exon 14 deletions of MET using differential primer pairs for identifying both the deleted and wild type gene copies.

⦁ MET alterations resulting in exon 14 skipping are found in lung cancer in both the presence and absence of MET gene amplification.

⦁ Exon 14 skipping causes increased signaling through the MET receptor pathway.

⦁ There is both preclinical and case report evidence suggesting that tumors harboring MET with exon 14 alterations and/or MET amplifications have increased sensitivity to MET inhibitors.

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