FISH

  • Genomic rearrangements of the PDGFRA, MET, and RET genes are associated with therapeutics in non-small cell lung carcinoma (NSCLC).
  • There is frequently limited FFPE material available and in the interest of utilizing scarce clinical samples, PacificDx has developed a four-color RET/PDGFRα/KIT/CC4 FISH probe.
  • The probe provides coverage of the PDGFRα gene (4q12), the KIT gene (4q12), a copy control probe located at 4p12 on chromosome 4 and detection of RET gene rearrangements (10q11.2).Example of four color FISH probe assay from PacificDx for detection of RET break apart and PDGFRAα gene amplification.

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