NSCLC Targeted Sequencing Panel by NGS

NGS squareNSCLC Targeted Sequencing Panel by NGS

Sequencing of uniquely indexed target enriched libraries is performed using an Illumina MiSeq instrument with bioinformatics analysis through an assay specific pipeline. This assay only reports the following variants in the following genes:

  • MET- reported areas include Point mutations and Ins/Del:
  • AXL- Chromosomal rearrangements including but not limited to MBIP-AXL (or alternative) and amplifications
  • KRAS- Point mutations involving codon 12, 13, 61
  • EGFR- Point mutations and Ins/Del: L858R, T790M, G719A/D/S, S768I, L861Q/R, Exon 20ins, Exon 19del
  • ALK- Rearrangements including but not limited to EML4-ALK
  • BRAF- Point mutations: V600E, V600D, V600K, V600R, G464V, G466E, G466E, G466A, G469V, G469L, G469R, G469A, N581S, N581T, D594N, D594H, D594G
  • ROS- Chromosomal rearrangements including but not limited to CD74-ROS, EZR-ROS, SDC4-ROS, SLC34A2-ROS, TPM3-ROS
  • RET- Point mutations including, but not limited to, C630R, C634R/W/Y, M918T, Chromosomal rearrangements including but not limited to KIF5B-RET or CCDC6
  • NTRK1-Chromosomal rearrangements including but not limited to MPRIP-NTRK1, CD74-NTRK1, TPM3-NTRK1, TFG-NTRK1
  • NTRK2-Point mutations: R715G, M713I, R734C

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