Category Archives: blog

Smooth Sailing Across a Changing Landscape: Researchdx/ Pacificdx Represents At The AGT 42nd Annual Meeting, St. Louis, MO June 15-17, 2017

The 42nd Association of Genetic Technologists (AGT) Annual Meeting highlighted the underlying theme of change. Change of professional landscape, AGT Board Management and culture. This theme was established starting from the Thursday workshops focused on Management, Molecular genetics techniques and the economics of novel Cytogenetic and Molecular workflows and propagated throughout the remaining conference agenda.…
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Surveying Genomic Landscapes in the Clinical Laboratory: DNA Views of Tumor Terrain

A web search for the term ‘genomic landscapes’ brings up a surprising number of publications from esteemed journals such as Cell, Science, and Nature Genetics. At first glance it would seem that the words ‘genomic’ and ‘landscape’ do not belong together. However, review of the many ‘genomic landscape’ publications from the past decade reveals a…
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Guidelines to the Galaxy of HER2 Testing in GEA Cancers

Say the words “HER2 gene amplification” and what immediately comes to mind is breast cancer. But did you know other cancers, including those of the stomach and esophagus (collectively called gastroesophagel adenocarinoma or GEA) can have too many (> 6) copies of the HER2 gene? That’s right, an estimated 20% of GEA cancers harbor an…
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FISHing for HER2 Stability on a Turbulent Chromosome 17

Have you ever wondered why so many high-risk breast cancer cases have HER2 equivocal results by FISH? That’s right, in an estimated 20% of the over 200,000 breast cancers diagnosed in the US every year, the FISH classification of the tumor’s HER2 gene copy number is reported as “EQUIVOCAL.” For clinicians trying to make decisions…
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