Recent Posts by Shelly Gunn MD PhD

FISHing for HER2 Stability on a Turbulent Chromosome 17

Have you ever wondered why so many high-risk breast cancer cases have HER2 equivocal results by FISH? That’s right, in an estimated 20% of the over 200,000 breast cancers diagnosed in the US every year, the FISH classification of the tumor’s HER2 gene copy number is reported as “EQUIVOCAL.” For clinicians trying to make decisions…
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Equivocal is Not a Genomic Subtype

Per NCCN guidelines, all newly diagnosed, recurrent, and metastatic breast cancers are evaluated for HER2 positivity. Tumors highly amplified for HER2 receptor protein expression are predicted to respond to anti-HER2 therapies. Thus, accurate reporting of the HER2 genomic subtype of each and every breast cancer is of critical importance for treatment planning and the patient’s…
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